{"id":34075,"date":"2024-10-18T11:05:37","date_gmt":"2024-10-18T09:05:37","guid":{"rendered":"https:\/\/neuronup.com\/?p=34075"},"modified":"2024-10-18T11:05:37","modified_gmt":"2024-10-18T09:05:37","slug":"pesquisa-esclerose-multipla-reabilitacao-cognitiva","status":"publish","type":"post","link":"https:\/\/neuronup.com\/br\/investigacao\/linhas-de-investigacao\/pesquisa-esclerose-multipla-reabilitacao-cognitiva\/","title":{"rendered":"Mudan\u00e7as neuropsicol\u00f3gicas e no volume da subst\u00e2ncia cinzenta, em pacientes com esclerose m\u00faltipla, ap\u00f3s uma terapia de reabilita\u00e7\u00e3o cognitiva assistida por computador com NeuronUP"},"content":{"rendered":"\n<p class=\"has-xl-font-size wp-block-paragraph\">Neste artigo falamos do <strong>estudo<\/strong> realizado para avaliar a efic\u00e1cia da aplica\u00e7\u00e3o de uma <strong>terapia de reabilita\u00e7\u00e3o cognitiva assistida por computador, NeuronUP, em pacientes com esclerose m\u00faltipla (EM).<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-table alignleft is-style-stripes has-md-font-size\"><table class=\"has-fixed-layout\"><tbody><tr><td><strong>Autores<\/strong><\/td><\/tr><tr><td>Julio Plata-Bello,&nbsp;<sup>*<\/sup>Mar\u00eda Yaiza P\u00e9rez-Mart\u00edn,&nbsp;Montserrat Gonz\u00e1lez-Platas,&nbsp;V\u00edctor Fajardo-Santana,&nbsp;KritsiaSinayFumero-Revetti<br><p>Servi\u00e7o de Neurocirurgia, Hospital Universit\u00e1rio de Canarias, San Crist\u00f3bal de La Laguna, Espanha<\/p><p>*Autor para correspond\u00eancia <a href=\"mailto:yaizaneuro@hotmail.com\">yaizaneuro@hotmail.com<\/a><\/p><\/td><\/tr><tr><td><strong>Declara\u00e7\u00e3o<\/strong><\/td><\/tr><tr><td>Os autores declaram n\u00e3o ter nenhum conflito de interesse.<\/td><\/tr><tr><td><strong>Refer\u00eancia<\/strong><\/td><\/tr><tr><td>EMJ Neurol.&nbsp;2018;6[1]:46-48.&nbsp;Abstract Review No. AR1.<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">Antecedentes<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Mais de 65% dos pacientes com esclerose m\u00faltipla (EM) costumam apresentar deteriora\u00e7\u00e3o cognitiva tanto nas fases iniciais como nas fases avan\u00e7adas da doen\u00e7a; essa deteriora\u00e7\u00e3o progride com o passar do tempo. A esclerose m\u00faltipla pode ter efeitos consider\u00e1veis na qualidade de vida, no ambiente de trabalho, no funcionamento di\u00e1rio e na independ\u00eancia dos pacientes.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">O tratamento cognitivo apresenta resultados contradit\u00f3rios, provavelmente porque as interven\u00e7\u00f5es e as medidas de desfecho s\u00e3o heterog\u00eaneas. Apesar disso, v\u00e1rios estudos demonstraram que a interven\u00e7\u00e3o neuropsicol\u00f3gica pode ter efeitos favor\u00e1veis sobre o desempenho cognitivo dos pacientes. Concretamente, existem provas de que <strong>a reabilita\u00e7\u00e3o cognitiva assistida por computador melhora o desempenho nos testes neuropsicol\u00f3gicos<\/strong>; por isso, foi desenhado um estudo para avaliar a efic\u00e1cia da aplica\u00e7\u00e3o de uma terapia de reabilita\u00e7\u00e3o cognitiva assistida por computador em pacientes com EM.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">M\u00e9todos<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Foram inclu\u00eddos 12 pacientes no estudo. Todos os pacientes tinham um diagn\u00f3stico de EM remitente-recorrente clinicamente est\u00e1vel, uma deteriora\u00e7\u00e3o cognitiva de leve a moderada segundo o estabelecido pela <em>Brief Repeatable Battery of Neuropsychological Tests<\/em> de Rao (BRB-N), um n\u00edvel adequado de acuidade visual e todos eram maiores de 18 anos. Avaliou-se os pacientes em tr\u00eas ocasi\u00f5es: no in\u00edcio do estudo, na oitava semana e na d\u00e9cima sexta semana.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Os pacientes foram agrupados aleatoriamente para receber tratamento ap\u00f3s a primeira avalia\u00e7\u00e3o (Grupo 1) ou ap\u00f3s a segunda avalia\u00e7\u00e3o (Grupo 2). Essa avalia\u00e7\u00e3o consistiu numa avalia\u00e7\u00e3o neuropsicol\u00f3gica (foram utilizadas vers\u00f5es alternativas da mesma bateria para reduzir os efeitos relacionados com a pr\u00e1tica), num estudo de resson\u00e2ncia magn\u00e9tica funcional (que incluiu uma resson\u00e2ncia magn\u00e9tica funcional em estado de repouso, uma imagem com tensor de difus\u00e3o e uma morfometria baseada em v\u00f3xel) e numa amostra de sangue para identificar as altera\u00e7\u00f5es plasm\u00e1ticas associadas ao fator neurotr\u00f3fico derivado do c\u00e9rebro, que participa nos processos de plasticidade neuronal. Foram adotadas estas medidas para identificar poss\u00edveis biomarcadores de efic\u00e1cia terap\u00eautica.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Todos os pacientes receberam <strong>24 sess\u00f5es de<\/strong> <strong>terapia cognitiva<\/strong> assistida por computador com o programa NeuronUP. NeuronUP \u00e9 uma plataforma web de neurorreabilita\u00e7\u00e3o que cont\u00e9m atividades que abrangem 40 processos neuropsicol\u00f3gicos. A dura\u00e7\u00e3o de <strong>cada sess\u00e3o<\/strong> de reabilita\u00e7\u00e3o foi de <strong>45 minutos<\/strong>, <strong>tr\u00eas vezes por semana durante 8 semanas<\/strong> no domic\u00edlio do paciente.<\/p>\n\n\n\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<aside class=\"wp-block-group pb-0 br-0101 has-background has-xl-margin-top\" style=\"background:linear-gradient(135deg,rgb(0,128,150) 0%,rgb(0,171,199) 100%)\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<div class=\"wp-block-columns br-1010 is-layout-flex wp-container-core-columns-is-layout-8f761849 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:60%\">\n<p class=\"has-text-align-center has-white-color has-text-color has-link-color has-xxl-font-size wp-elements-1 has-no-margin-top has-no-margin-bottom wp-block-paragraph\"> <strong>Trabalhe na NeuronUP<\/strong><\/p>\n\n\n\n<p class=\"has-text-align-center has-white-color has-text-color has-link-color has-sm-font-size wp-elements-2 has-no-margin-top has-no-margin-bottom wp-block-paragraph\">Desenvolva sua carreira no setor da sa\u00fade digital.<br>Junte-se \u00e0 nossa equipe.<\/p>\n\n\n\n<div style=\"height:10px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-buttons is-content-justification-center is-layout-flex wp-container-core-buttons-is-layout-fe48e5de wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button has-custom-width wp-block-button__width-75\" style=\"--button-background:var(--color-custom-1);--button-background-hover:#cc7e00;\"><a class=\"wp-block-button__link button   has-sm-font-size has-custom-font-size wp-element-button\" href=\"https:\/\/neuronup.com\/br\/as-melhores-ofertas-de-emprego-para-profissionais-da-neurorreabilitacao\/\"><strong><strong>Ver vagas dispon\u00edveis<\/strong><\/strong><\/a><\/div>\n\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:40%\"><div class=\"wp-block-image blog-br-0101\">\n<figure class=\"alignright size-large is-resized has--xxxl-margin-top has-no-margin-bottom\"><img decoding=\"async\" width=\"1024\" height=\"1024\" src=\"https:\/\/neuronup.com\/br\/wp-content\/uploads\/2026\/06\/Historias-exito-NeuronUP-14-2-1024x1024.webp\" alt=\"\" class=\"wp-image-51286\" style=\"width:361px;height:auto\" srcset=\"https:\/\/neuronup.com\/br\/wp-content\/uploads\/2026\/06\/Historias-exito-NeuronUP-14-2-24x24.webp 24w, https:\/\/neuronup.com\/br\/wp-content\/uploads\/2026\/06\/Historias-exito-NeuronUP-14-2-48x48.webp 48w, https:\/\/neuronup.com\/br\/wp-content\/uploads\/2026\/06\/Historias-exito-NeuronUP-14-2-80x80.webp 80w, https:\/\/neuronup.com\/br\/wp-content\/uploads\/2026\/06\/Historias-exito-NeuronUP-14-2-96x96.webp 96w, https:\/\/neuronup.com\/br\/wp-content\/uploads\/2026\/06\/Historias-exito-NeuronUP-14-2-150x150.webp 150w, https:\/\/neuronup.com\/br\/wp-content\/uploads\/2026\/06\/Historias-exito-NeuronUP-14-2-300x300.webp 300w, https:\/\/neuronup.com\/br\/wp-content\/uploads\/2026\/06\/Historias-exito-NeuronUP-14-2-768x768.webp 768w, https:\/\/neuronup.com\/br\/wp-content\/uploads\/2026\/06\/Historias-exito-NeuronUP-14-2-1024x1024.webp 1024w, https:\/\/neuronup.com\/br\/wp-content\/uploads\/2026\/06\/Historias-exito-NeuronUP-14-2.webp 1080w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n<\/div><\/div>\n<\/div>\n<\/div><\/aside>\n\n\n\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">Resultados&nbsp;<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Os resultados preliminares mostraram <strong>melhorias significativas na mem\u00f3ria verbal<\/strong>, <strong>na mem\u00f3ria visual diferida, na mem\u00f3ria de trabalho e na flu\u00eancia sem\u00e2ntica<\/strong>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">A an\u00e1lise dos dados da RM estrutural (morfometria baseada em v\u00f3xel) mostrou um <strong>aumento de 0,7% no volume total de subst\u00e2ncia cinzenta<\/strong> na maioria dos pacientes. Al\u00e9m disso, os estudos de RM funcional em estado de repouso revelaram uma diminui\u00e7\u00e3o da amplitude fracionada das flutua\u00e7\u00f5es de baixa frequ\u00eancia no c\u00f3rtex cingulado \u2014regi\u00e3o implicada nos processos de aprendizagem e mem\u00f3ria\u2014 e na \u00e1rea frontal m\u00e9dia (Figura 1), o que<strong> sugere que a reabilita\u00e7\u00e3o cognitiva <\/strong>melhora o desempenho cognitivo e<strong> pode provocar mudan\u00e7as estruturais e funcionais nos c\u00e9rebros dos pacientes com EM<\/strong>.<\/p>\n\n\n\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image image-interface\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"594\" height=\"408\" src=\"https:\/\/neuronup.com\/br\/wp-content\/uploads\/2024\/10\/cambios-neuropsicologicos-y-en-el-volumen-de-sustencia-gris-en-pacientes-con-esclerosis-multiple.webp\" alt=\"RM cerebral fMRI mostra mudan\u00e7as na subst\u00e2ncia cinzenta ap\u00f3s reabilita\u00e7\u00e3o cognitiva em EM; destaca cingulada e frontal m\u00e9dia.\" class=\"wp-image-34077\" srcset=\"https:\/\/neuronup.com\/br\/wp-content\/uploads\/2024\/10\/cambios-neuropsicologicos-y-en-el-volumen-de-sustencia-gris-en-pacientes-con-esclerosis-multiple-300x206.webp 300w, https:\/\/neuronup.com\/br\/wp-content\/uploads\/2024\/10\/cambios-neuropsicologicos-y-en-el-volumen-de-sustencia-gris-en-pacientes-con-esclerosis-multiple.webp 594w\" sizes=\"(max-width: 594px) 100vw, 594px\" \/><figcaption class=\"wp-element-caption\">Diminui\u00e7\u00e3o da amplitude fracionada das flutua\u00e7\u00f5es de baixa frequ\u00eancia no c\u00f3rtex cingulado e na \u00e1rea frontal m\u00e9dia ap\u00f3s o tratamento.<\/figcaption><\/figure>\n<\/div>\n\n\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">Conclus\u00e3o<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Estes resultados indicam que <strong>a terapia de reabilita\u00e7\u00e3o cognitiva<\/strong> pode favorecer a neuroplasticidade ao induzir mudan\u00e7as na reorganiza\u00e7\u00e3o cortical, o que <strong>contribuir\u00e1 para melhorar a reserva cognitiva ou cerebral<\/strong>.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Bibliografia<\/h2>\n\n\n\n<ul class=\"wp-block-list has-sm-font-size\">\n<li>Amato MP et al. Multiple sclerosis-related cognitive changes: A review of cross-sectional and longitudinal studies. J Neurol Sci. 2006;245(1-2):41-5.<\/li>\n\n\n\n<li>De Giglio L et al. A low-cost cognitive rehabilitation with a commercial video game improves sustained attention and executive functions in multiple sclerosis: A pilot study. Neurorehabil Neural Repair. 2015;29(5):453-61.<\/li>\n\n\n\n<li>Shatil E et al. Home-based personalized cognitive training in MS patients: A study of adherence and cognitive performance. Neuro Rehabilitation. 2010;26(2):143-53.<\/li>\n\n\n\n<li>Filippi M et al. Multiple sclerosis: Effects of cognitive rehabilitation on structural and functional MR imaging measures&#8211;An explorative study. Radiology. 2012;262(3):932-40.<\/li>\n\n\n\n<li>Mu\u00f1oz C\u00e9spedes JM, Tirapu Ust\u00e1rroz Rehabilitation programs for executive functions. Rev Neurol. 2004;38(7):656-63.<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">Se voc\u00ea gostou deste artigo de pesquisa sobre esclerose m\u00faltipla, talvez se interesse por estes artigos da NeuronUP.<\/h3>\n\n\n\n<div class=\"mai-grid entries entries-grid has-boxed has-image-full\" style=\"--entry-title-font-size:var(--font-size-lg);--align-text:start;--entry-meta-text-align:start;\"><div class=\"entries-wrap has-columns\" style=\"--columns-xs:1 \/ 1;--columns-sm:1 \/ 1;--columns-md:1 \/ 3;--columns-lg:1 \/ 3;--flex-xs:0 0 var(--flex-basis);--flex-sm:0 0 var(--flex-basis);--flex-md:0 0 var(--flex-basis);--flex-lg:0 0 var(--flex-basis);--column-gap:var(--spacing-lg);--row-gap:var(--spacing-lg);--align-columns:start;\"><article class=\"entry entry-grid is-column has-entry-link has-image has-image-first type-post category-transtorno-de-linguagem tag-linguagem tag-ninos tag-trastornos-del-neurodesarrollo\" style=\"--entry-index:1;\" aria-label=\"A dislexia como barreira na inf\u00e2ncia\" itemscope itemtype=\"https:\/\/schema.org\/CreativeWork\"><a class=\"entry-image-link\" href=\"https:\/\/neuronup.com\/br\/noticias-de-estimulacao-cognitiva\/transtorno-de-linguagem\/a-dislexia-na-infancia\/\" tabindex=\"-1\" aria-hidden=\"true\"><img decoding=\"async\" width=\"400\" height=\"300\" src=\"https:\/\/neuronup.com\/br\/wp-content\/uploads\/2024\/09\/dislexia-infancia-400x300.webp\" class=\"entry-image size-landscape-sm\" alt=\"Livro aberto sustentado por duas m\u00e3os, letras e s\u00edmbolos saem do interior em um design gr\u00e1fico que ilustra a dislexia.\" srcset=\"https:\/\/neuronup.com\/br\/wp-content\/uploads\/2024\/09\/dislexia-infancia-400x300.webp 400w, https:\/\/neuronup.com\/br\/wp-content\/uploads\/2024\/09\/dislexia-infancia-800x600.webp 800w\" sizes=\"(max-width:599px) 599px, (min-width:600px) and (max-width: 799px) 799px, (min-width:800px) and (max-width: 999px) 333px, (min-width:1000px) 400px\" \/><\/a><div class=\"entry-wrap entry-wrap-grid\"><h3 class=\"entry-title\" itemprop=\"headline\"><a class=\"entry-title-link\" href=\"https:\/\/neuronup.com\/br\/noticias-de-estimulacao-cognitiva\/transtorno-de-linguagem\/a-dislexia-na-infancia\/\" rel=\"bookmark\">A dislexia como barreira na inf\u00e2ncia<\/a><\/h3>\n<\/div><\/article><article class=\"entry entry-grid is-column has-entry-link has-image has-image-first type-post category-disforia-de-genero tag-ninos\" style=\"--entry-index:2;\" aria-label=\"Disforia de g\u00eanero na inf\u00e2ncia e na adolesc\u00eancia. 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treinamento cognitivo\" itemscope itemtype=\"https:\/\/schema.org\/CreativeWork\"><a class=\"entry-image-link\" href=\"https:\/\/neuronup.com\/br\/investigacao\/linhas-de-investigacao\/avaliacao-intensiva-das-funcoes-executivas-derivada-do-desempenho-em-jogos-de-treinamento-cognitivo\/\" tabindex=\"-1\" aria-hidden=\"true\"><img decoding=\"async\" width=\"400\" height=\"300\" src=\"https:\/\/neuronup.com\/br\/wp-content\/uploads\/2024\/11\/Evaluacion-intensiva-de-las-funciones-ejecutivas-derivada-del-rendimiento-en-juegos-de-entrenamiento-cognitivo-NeuronUP-400x300.webp\" class=\"entry-image size-landscape-sm\" alt=\"Homem idoso com cabelo grisalho e \u00f3culos, camisa de estampa floral, em um corredor interno com plantas e luz natural, olhando para a c\u00e2mera.\" srcset=\"https:\/\/neuronup.com\/br\/wp-content\/uploads\/2024\/11\/Evaluacion-intensiva-de-las-funciones-ejecutivas-derivada-del-rendimiento-en-juegos-de-entrenamiento-cognitivo-NeuronUP-400x300.webp 400w, https:\/\/neuronup.com\/br\/wp-content\/uploads\/2024\/11\/Evaluacion-intensiva-de-las-funciones-ejecutivas-derivada-del-rendimiento-en-juegos-de-entrenamiento-cognitivo-NeuronUP-800x600.webp 800w\" sizes=\"(max-width:599px) 599px, (min-width:600px) and (max-width: 799px) 799px, (min-width:800px) and (max-width: 999px) 333px, (min-width:1000px) 400px\" \/><\/a><div class=\"entry-wrap entry-wrap-grid\"><h3 class=\"entry-title\" itemprop=\"headline\"><a class=\"entry-title-link\" href=\"https:\/\/neuronup.com\/br\/investigacao\/linhas-de-investigacao\/avaliacao-intensiva-das-funcoes-executivas-derivada-do-desempenho-em-jogos-de-treinamento-cognitivo\/\" rel=\"bookmark\">Avalia\u00e7\u00e3o intensiva das fun\u00e7\u00f5es executivas derivada do desempenho em jogos de treinamento cognitivo<\/a><\/h3>\n<\/div><\/article><article class=\"entry entry-grid is-column has-entry-link has-image has-image-first type-post category-alzheimer tag-actividades-de-estimulacion-cognitiva tag-doenca-de-alzheimer tag-maiores\" style=\"--entry-index:5;\" aria-label=\"Oficina cognitiva com NeuronUP para idosos com Alzheimer\" itemscope itemtype=\"https:\/\/schema.org\/CreativeWork\"><a class=\"entry-image-link\" href=\"https:\/\/neuronup.com\/br\/noticias-de-estimulacao-cognitiva\/doencas-neurodegenerativas\/alzheimer\/oficina-cognitiva-com-neuronup-para-pessoas-idosas-com-alzheimer\/\" tabindex=\"-1\" aria-hidden=\"true\"><img decoding=\"async\" width=\"400\" height=\"300\" src=\"https:\/\/neuronup.com\/br\/wp-content\/uploads\/2025\/02\/Actividad-de-NeuronUP-para-la-intervencion-de-personas-mayores-con-alzheimer-Post-it-ordenados-1-400x300.webp\" class=\"entry-image size-landscape-sm\" alt=\"Interface tipo quadro de corti\u00e7a com tr\u00eas folhas bege, n\u00fameros 1 e 2, bot\u00e3o Pronto, contador 0\/5 e \u00edcones de cora\u00e7\u00e3o e reprodu\u00e7\u00e3o.\" srcset=\"https:\/\/neuronup.com\/br\/wp-content\/uploads\/2025\/02\/Actividad-de-NeuronUP-para-la-intervencion-de-personas-mayores-con-alzheimer-Post-it-ordenados-1-400x300.webp 400w, https:\/\/neuronup.com\/br\/wp-content\/uploads\/2025\/02\/Actividad-de-NeuronUP-para-la-intervencion-de-personas-mayores-con-alzheimer-Post-it-ordenados-1-800x600.webp 800w, https:\/\/neuronup.com\/br\/wp-content\/uploads\/2025\/02\/Actividad-de-NeuronUP-para-la-intervencion-de-personas-mayores-con-alzheimer-Post-it-ordenados-1-1200x900.webp 1200w\" sizes=\"(max-width:599px) 599px, (min-width:600px) and (max-width: 799px) 799px, (min-width:800px) and (max-width: 999px) 333px, (min-width:1000px) 400px\" \/><\/a><div class=\"entry-wrap entry-wrap-grid\"><h3 class=\"entry-title\" itemprop=\"headline\"><a class=\"entry-title-link\" href=\"https:\/\/neuronup.com\/br\/noticias-de-estimulacao-cognitiva\/doencas-neurodegenerativas\/alzheimer\/oficina-cognitiva-com-neuronup-para-pessoas-idosas-com-alzheimer\/\" rel=\"bookmark\">Oficina cognitiva com NeuronUP para idosos com Alzheimer<\/a><\/h3>\n<\/div><\/article><article class=\"entry entry-grid is-column has-entry-link has-image has-image-first type-post category-recursos-humanos\" style=\"--entry-index:6;\" aria-label=\"Conhe\u00e7a Carolina Sastre, o rigor e o cora\u00e7\u00e3o cl\u00ednico da NeuronUP\" itemscope itemtype=\"https:\/\/schema.org\/CreativeWork\"><a class=\"entry-image-link\" href=\"https:\/\/neuronup.com\/br\/recursos-humanos\/conheca-carolina-sastre-o-rigor-e-o-coracao-clinico-da-neuronup\/\" tabindex=\"-1\" aria-hidden=\"true\"><img decoding=\"async\" width=\"400\" height=\"300\" src=\"https:\/\/neuronup.com\/br\/wp-content\/uploads\/2026\/08\/br-Historias-exito-NeuronUP-7-italiano-400x300.webp\" class=\"entry-image size-landscape-sm\" alt=\"\" srcset=\"https:\/\/neuronup.com\/br\/wp-content\/uploads\/2026\/08\/br-Historias-exito-NeuronUP-7-italiano-400x300.webp 400w, https:\/\/neuronup.com\/br\/wp-content\/uploads\/2026\/08\/br-Historias-exito-NeuronUP-7-italiano-800x600.webp 800w\" sizes=\"(max-width:599px) 599px, (min-width:600px) and (max-width: 799px) 799px, (min-width:800px) and (max-width: 999px) 333px, (min-width:1000px) 400px\" \/><\/a><div class=\"entry-wrap entry-wrap-grid\"><h3 class=\"entry-title\" itemprop=\"headline\"><a class=\"entry-title-link\" href=\"https:\/\/neuronup.com\/br\/recursos-humanos\/conheca-carolina-sastre-o-rigor-e-o-coracao-clinico-da-neuronup\/\" rel=\"bookmark\">Conhe\u00e7a Carolina Sastre, o rigor e o cora\u00e7\u00e3o cl\u00ednico da NeuronUP<\/a><\/h3>\n<\/div><\/article><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Neste artigo falamos do estudo realizado para avaliar a efic\u00e1cia da aplica\u00e7\u00e3o de uma terapia de reabilita\u00e7\u00e3o cognitiva assistida por computador, NeuronUP, em pacientes com esclerose m\u00faltipla (EM). Autores Julio Plata-Bello,&nbsp;*Mar\u00eda Yaiza P\u00e9rez-Mart\u00edn,&nbsp;Montserrat Gonz\u00e1lez-Platas,&nbsp;V\u00edctor Fajardo-Santana,&nbsp;KritsiaSinayFumero-Revetti Servi\u00e7o de Neurocirurgia, Hospital Universit\u00e1rio de Canarias, San Crist\u00f3bal de La Laguna, Espanha *Autor para correspond\u00eancia yaizaneuro@hotmail.com Declara\u00e7\u00e3o Os autores &hellip;<\/p>\n","protected":false},"author":7,"featured_media":51216,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_genesis_hide_title":false,"_genesis_hide_breadcrumbs":false,"_genesis_hide_singular_image":false,"_genesis_hide_footer_widgets":false,"_genesis_custom_body_class":"","_genesis_custom_post_class":"","_genesis_layout":"","footnotes":""},"categories":[684],"tags":[773,754],"class_list":["type-post","category-linhas-de-investigacao","tag-esclerosis-multiple","tag-investigacion","entry"],"acf":[],"_links":{"self":[{"href":"https:\/\/neuronup.com\/br\/wp-json\/wp\/v2\/posts\/34075","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/neuronup.com\/br\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/neuronup.com\/br\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/neuronup.com\/br\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/neuronup.com\/br\/wp-json\/wp\/v2\/comments?post=34075"}],"version-history":[{"count":0,"href":"https:\/\/neuronup.com\/br\/wp-json\/wp\/v2\/posts\/34075\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/neuronup.com\/br\/wp-json\/wp\/v2\/media\/51216"}],"wp:attachment":[{"href":"https:\/\/neuronup.com\/br\/wp-json\/wp\/v2\/media?parent=34075"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/neuronup.com\/br\/wp-json\/wp\/v2\/categories?post=34075"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/neuronup.com\/br\/wp-json\/wp\/v2\/tags?post=34075"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}